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FINDING CURES TOGETHER<sup>SM</sup>

Stand Up To Cancer Dream Teams and Translational Teams

At the heart of Stand Up To Cancer’s (SU2C’s) research program is the Dream Team approach. A Dream Team is a scientific task force, a collaboration of top researchers at different institutions who come together to develop new and improved approaches to cancer. By pooling their knowledge and their resources and working together for common goals, they can make progress faster and move therapies and treatments from the laboratory to doctors’ offices, where they can benefit patients.

SU2C’s distinctive approach to funding cancer research was specifically designed to eliminate barriers to creativity and collaboration by enabling scientists with different areas of expertise from different institutions across the country and around the world to work together. The approach breaks down the “silos” that in the past have often kept scientists from working together.

The American Association for Cancer Research (AACR) has been the Scientific Partner of SU2C since it was launched in 2008, providing scientific leadership, expert peer review, scientific oversight, and grants administration. The Scientific Advisory Committee (SAC), led by Nobel Laureate Phillip A. Sharp, PhD, is dedicated to seeking out the most innovative and promising cancer research projects for funding by SU2C. Joint Scientific Advisory Committees (JSACs) are formed to review applications for grants funded jointly by SU2C and partner organizations. For each grant opportunity the SAC or JSAC conduct innovative, interactive, rapid, and rigorous scientific reviews of Dream Team ideas via a multistep process. The AACR is responsible for administering the Dream Team grants, distributing the funds to the Dream Team leaders’ institutions, following the Dream Teams’ progress, and providing scientific oversight through program management and evaluation of the Dream Teams’ achievements during the funding period. The AACR and the Scientific Advisory Committees conduct regular reviews to ensure that milestones and objectives are being satisfactorily achieved.

As of August 2015, 16 Dream Teams have been launched, along with two smaller Translational Research Teams and 26 individual Innovative Research Grants.  The total amount of funding committed is more than $205 million. For details on the Dream Teams and Translational Teams, please click on the links below.

2015 Dream Teams

SU2C-American Cancer Society Dream Team: Targeting KRAS Mutant Lung Cancers
Leader: Jeffrey A. Engelman, MD, PhD, Massachusetts General Hospital Cancer Center
Co-leader: Jedd D. Wolchok, MD, PhD, Memorial Sloan Kettering Cancer Center
Grant Term: August 2015 – July 2018 Total Funding: $20 million

SU2C-Ovarian Cancer Research Fund-Ovarian Cancer National Alliance-National Ovarian Cancer Coalition Dream Team: DNA Repair Therapies for Ovarian Cancer
Leader: Alan D. D’Andrea, MD, Dana-Farber Cancer Institute
Co-leader: Elizabeth M. Swisher, MD, University of Washington
Grant Term: July 2015 – June 2018 Total Funding: $6 million

SU2C-Dutch Cancer Society Dream Team: Molecular Early Detection of Colorectal Cancer - MEDOCC
Leader: Gerrit A. Meijer, MD, The Netherlands Cancer Institute
Co-leader: Victor E. Velculescu, MD, PhD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Grant Term: April 2015 – March 2018 Total Funding: €6 million

Van Andel Research Institute-SU2C Epigenetics Dream Team
Leaders:  Peter A. Jones, PhD, DSc, Van Andel Research Institute; Stephen B. Baylin, MD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Grant Term: October 2014 – September 2017 Total Funding: $7.5 million

2014 Dream Teams

SU2C-Lustgarten Foundation Dream Team: Transforming Pancreatic Cancer from Death Sentence to Treatable Disease

Leader: Elizabeth M. Jaffee, MD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Co-leader: Robert H. Vonderheide, MD, DPhil, Abramson Cancer Center, University of Pennsylvania
Grant Term: July 2014 – June 2017 Total Funding: $8 million

SU2C-Dutch Cancer Society Dream Team: Tumor Organoids: A New Pre-Clinical Model for Drug Sensitivity Analysis
Leader: Hans Clevers, MD, PhD, Hubrecht Institute [Current institution: The Netherlands Cancer Institute]
Co-leader: Johannes L. Bos, PhD, University Medical Center (UMC) Utrecht
Grant Term: April 2014 – March 2018 Total Funding: €6 million

2014 Translational Grant

SU2C-Farrah Fawcett Foundation Translational Team: Therapeutic CD8 Vaccines Against Conserved E7 HPV Epitopes Identified by MS
Leader: Ellis L. Reinherz, MD, Dana-Farber Cancer Institute
Co-leader: Robert I. Haddad, MD, Dana-Farber Cancer Institute
Grant Term: July 2014 – June 2017 Total Funding: $1.2 million

2013 Dream Teams

SU2C-St Baldrick’s Dream Team: Immunogenomics to Create New Therapies for High-¬Risk Childhood Cancers
Leader: John M. Maris, MD, The Children’s Hospital of Philadelphia
Co-leader: Crystal L. Mackall, MD, National Cancer Institute
Grant Term: July 2013 – June 2017 Total Funding: $14.5 million

SU2C-Cancer Research Institute Dream Team: Immunologic Checkpoint Blockade and Adoptive Cell Transfer in Cancer Therapy
Leaders: James P. Allison, PhD, The University of Texas MD Anderson Cancer Center ; and Antoni Ribas, MD, PhD, University of California, Los Angeles (UCLA)
Co-leaders: Drew M. Pardoll, MD, PhD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; and Cassian Yee, MD, The University of Texas MD Anderson Cancer Center
Grant Term: March 2013 – February 2016 Total Funding: $11 million

SU2C-Prostate Cancer Foundation Dream Team: Targeting Adaptive Pathways in Metastatic Treatment¬-Resistant Prostate Cancer
Leader: Eric J. Small, MD, University of California, San Francisco (UCSF)
Co-leader: Owen N. Witte, MD, University of California, Los Angeles (UCLA)
Grant Term: January 2013 – December 2015 Total Funding: $10 million

2013 Translational Team

SU2C-Dutch Cancer Society International Team: Prospective Use of DNA-guided Personalized Cancer Treatment
Leader:  Emile E. Voest, MD, PhD, University Medical Center (UMC) Utrecht in the Netherlands [Current institution: The Netherlands Cancer Institute]
Co-leader: René Bernards, PhD, The Netherlands Cancer Institute
Grant Term: April 2014 – March 2018 Total Funding: €1.2 million

2012 Dream Teams

SU2C-Prostate Cancer Foundation Dream Team: Precision Therapy of Advanced Prostate Cancer
Leader: Arul M. Chinnaiyan, MD, PhD, University of Michigan
Co-leader: Charles L. Sawyers, MD, Memorial Sloan¬ Kettering Cancer Center
Grant Term: August 2012 – July 2016 Total Funding: $10 million

SU2C-Melanoma Research Alliance Dream Team: Personalized Medicine for Patients With BRAF Wild-Type (BRAFwt) Cancer
Leader: Jeffrey M. Trent, PhD, FACMG, The Translational Genomics Research Institute (TGen)
Co-leader: Patricia M. LoRusso, DO, Yale Cancer Center [Previously: Karmanos Cancer Institute and Wayne State University School of Medicine]
Grant Term: April 2012 – December 2015 Total Funding: $6 million

2009 Dream Teams

SU2C Epigenetic Dream Team: Bringing Epigenetic Therapy to the Forefront of Cancer Management
Leader: Stephen B. Baylin, MD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Co-leader: Peter A. Jones, PhD, DSc, University of Southern California [Current Institution: Van Andel Research Institute]
Grant Term: December 2009 – January 2015 Total Funding: $10.2 million

SU2C PI3K Dream Team: Targeting the PI3K Pathway in Women's Cancers
Leader: Lewis C. Cantley, PhD, Beth Israel Deaconess Medical Center [Current Institution: Meyer Cancer Center at Weill Cornell Medical College]
Co-leader: Gordon B. Mills, MD, PhD, The University of Texas MD Anderson Cancer Center
Grant Term: November 2009 – October 2013 Total Funding: $14.9 million

SU2C Circulating Tumor Cell Chip Dream Team: Bioengineering and Clinical Applications of Circulating Tumor Cell Chip
Leader: Daniel A. Haber, MD, PhD, Massachusetts General Hospital Cancer Center
Co-leader: Mehmet Toner, PhD, Massachusetts General Hospital
Grant Term: December 2009 – November 2013 Total Funding: $15 million

SU2C Pancreatic Cancer Dream Team: Cutting off the Fuel Supply: A New Approach to the Treatment of Pancreatic Cancer
Leader: Craig B. Thompson, MD, Abramson Cancer Center, University of Pennsylvania [Current Institution: Memorial Sloan Kettering Cancer Center]
Co-leader: Daniel D. Von Hoff, MD, FACP, The Translational Genomics Research Institute (TGen)
Grant Term: December 2009 – May 2015 Total Funding: $22.25 million

SU2C Breast cancer Dream Team: An Integrated Approach to Targeting Breast Cancer Molecular Subtypes and Their Resistance Phenotypes
Leaders: Dennis J. Slamon, MD, PhD, UCLA's Jonsson Comprehensive Cancer Center
Co-leader: Joe W. Gray, PhD, Lawrence Berkeley National Laboratory [Current institution: Oregon Health and Science University]
Grant Term: October 2009 – September 2013 Total Funding: $17.5 million

 

For non-media related SU2C questions, please send an email to SU2C@aacr.org.