AACR Grantees Share their Findings
We are extremely proud of our past and present grantees who presented and published their findings this past year. Their accomplishments have been made possible, thanks to the support of the AACR and its funding partners.
JANUARY
Tumor development in individuals with high breast density
- Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk, Jason Northey, PhD,2015 AACR Basic Cancer Research Fellowship and 2017 AACR-Janssen Fellowship in Cancer Interception Research
Simultaneous lymphovascular and immune infiltrate analysis in melanoma
- Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma, Amanda Lund, PhD,2022AACR-Bristol Myers Squibb Midcareer Female Investigator Grant
FEBRUARY
PARP inhibitors: not just for solid tumors
- R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts, Hai Dang Nguyen, PhD,2022 AACR Career Development Award to Further Diversity, Equity, and Inclusion in Cancer Research
3D Models to test the impact of tumor-treating fields
- Development and Optimisation of Tumour Treating Fields (TTFields) Delivery within 3D Primary Glioma Stem Cell-like Models of Spatial Heterogeneity, Spencer Collis, PhD,2021 AACR-Novocure Tumor Treating Fields Research Grant
Neutrophils’ role in chronic stress-induced cancer metastasis
- Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment, Xue-Yan He, PhD,2021AACR-AstraZeneca Breast Cancer Research Fellowship
Baseline attitudes toward nicotine replacement therapy versus smoking cessation adherence
- Predictors of Nicotine Replacement Therapy Adherence: Mixed-Methods Research With a Convergent Parallel Design,Mary E. Cooley, PhD,2019AACR-Johnson & Johnson Lung Cancer Innovation Science Grant
MARCH
Racial disparities in endocrine therapy adherence
- Barriers to endocrine therapy adherence: perspectives of Black breast cancer survivors and their providers, Kimberley Lee, MD, MHS,2021 Breast Cancer Research Foundation-AACR Career Development Award to Promote Diversity and Inclusion
Tumor-treating fields: a potential treatment for spinal metastases
- Tumor treating fields suppress tumor cell growth and neurologic decline in models of spinal metastases, Christopher A. Alvarez-Breckenridge, MD, PhD, 2023 AACR-Novocure Career Development Award for Cancer Research and Claudio E. Tatsui, MD, 2021 AACR-Novocure Tumor Treating Fields Research Grant
APRIL
Addressing racial disparities in lung cancer
- Actívatexto: Feasibility and Acceptability of a Mobile Intervention That Promotes Smoking Cessation and Physical Activity among Latinos, Francisco Cartujano Barrera, PhD,2021 AACR-Genentech Cancer Disparities Research Fellowship
New modulator of acinar-to-ductal metaplasia in pancreatic cancer
- Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases, Geou-Yarh Liou, PhD,2017 AACR-Bayer Innovation and Discovery Grant
Novel treatment combination with tumor-treating fields in glioma
- Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner, Matthew R. Sarkisian, PhD, 2022 AACR-Novocure Tumor Treating Fields Research Grant
MAY-JUNE
Radiosensitizing rhabdomyosarcoma by targeting metabolic vulnerabilities
- Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo, Rutulkumar Patel, MS, PhD, 2021 AACR-QuadW Foundation Fellowship for Clinical/Translational Sarcoma Research
Lymphatic vessels: enabling defense on two fronts
Amanda Lund, PhD,2022AACR-Bristol Myers Squibb Midcareer Female Investigator Grant
JULY
Revolutionizing uveal melanoma treatment: SCANDIUM-II trial
- A phase Ib randomized multicenter trial of isolated hepatic perfusion in combination with ipilimumab and nivolumab for uveal melanoma metastases (SCANDIUM II trial), Roger Oloffson Bagge, MD, 2021 AACR-Ocular Melanoma Foundation Career Development Award, in Honor of Robert C. Allen, MD
A closer look at global MGUS disparity
- Prevalence of monoclonal gammopathy of undetermined significance in Eswatini: a population-based study in Africa, Kara Cicero, MD, MPH, 2019 AACR-Takeda Oncology Myeloma Research Fellowship
A one up in the battle against multiple myeloma
- NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome, Amin Sobh, PhD, 2022 AACR-Bristol Myers Squibb Cancer Disparities Research Fellowship
Predicting uveal melanoma metastasis
Alison H. Skalet, MD, PhD, 2018 AACR-Ocular Melanoma Foundation Career Development Award
AUGUST-DECEMBER
Exploring a link between periodontal disease and lung cancer
- Blood Leukocyte DNA Methylation Markers of Periodontal Disease and Risk of Lung Cancer in a Case-Control Study Nested in the CLUE II Cohort, Dominique Michaud, ScD, 2018 AACR-Johnson & Johnson Lung Cancer Innovation Science Grant
Therapeutic potential of targeting bromodomain-independent functions of BET proteins
- Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity, Sicong Zhang, PhD, 2018 AACR-John and Elizabeth Leonard Family Foundation Basic Cancer Research Fellowship
Enhancing cellular therapy in ovarian cancer
- Transgelin 2 guards T cell lipid metabolism and antitumour function, Sung-Min Hwang, PhD, 2022 AACR-Bristol Myers Squibb Immuno-oncology Research Fellowship
Adjuvant Topical Therapy for Cervical Precancer Treatment
- Safety and adherence to self‐administered intravaginal 5‐fluorouracil cream following cervical intraepithelial neoplasia (CIN) 2/3 treatment among HIV‐positive women in Kenya: A phase 1 clinical trial, Chemtai Mungo, MD, MPH, FACOG, 2021 Victoria’s Secret Global Fund for Women’s Cancers Career Development Award, in Partnership with Pelotonia & AACR