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AACR Annual Meeting Presentations Published Simultaneously in AACR Journals

April 13, 2021

PHILADELPHIA – The American Association for Cancer Research (AACR) is hosting Week 1 of the AACR Annual Meeting 2021 virtually April 10-15, 2021. The AACR Annual Meeting features the latest discoveries across the spectrum of cancer research, from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy. This year, 10 Annual Meeting presentations were simultaneously published in the following AACR journals:

Blood Cancer Discovery

Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma

Tracking clonal hematopoiesis in patients with classical Hodgkin lymphoma

ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment

A critical role for SIRT5 in acute myeloid leukemia metabolism

  • Meeting abstract
  • Presenter: Dongqing Yan, PhD, Huntsman Cancer Institute at the University of Utah, Salt Lake City
  • Journal article
  • Corresponding author: Michael W. Deininger, MD, PhD, Huntsman Cancer Institute at the University of Utah, Salt Lake City
  • Spotlight: Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia
  • Corresponding author: Ari Melnick, MD, Weill Cornell Medicine, New York

Prognostic and therapeutic significance of leukemia subtypes in the context of risk-directed therapy based on minimal residual disease levels in pediatric acute lymphoblastic leukemia

  • Meeting abstract
  • Presenter: Sima Jeha, MD, St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Journal article
  • Corresponding author: Ching-Hon Pui, MD, St. Jude Children’s Research Hospital, Memphis, Tennessee

Cancer Discovery

Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis

Werner helicase is a synthetic-lethal vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy and Immunotherapy

CAR T cell therapy reshapes the tumor microenvironment to promote host antitumor immune repsonses in glioblastoma

  • Meeting abstract
  • Journal article
  • Presenter and corresponding author: Christine E. Brown, PhD, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, California

Cancer Immunology Research

Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy

  • Meeting abstract
  • Presenter: Chiara Berlato, PhD, Barts Cancer Institute, Queen Mary University of London
  • Journal article
  • Corresponding author: Frances R. Balkwill, PhD, Barts Cancer Institute, Queen Mary University of London

Exercise training boosts CTL infiltration and sensitizes tumors to immune checkpoint blockade

  • Meeting abstract
  • Presenter: Igor L. Gomes-Santos, PhD, Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Boston
  • Journal article
  • Corresponding author: Dai Fukumura, MD, PhD, Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Boston

Members of the media are invited to attend all AACR Annual Meeting sessions. Journalists can request complimentary meeting registration from the AACR public relations team using the form on the AACR website. Please contact Kathleen Venango at [email protected] with any questions related to meeting registration.