Cancer Preventive Vaccine Showed Promising Results in Preclinical Model of Lynch Syndrome
“ATLANTA – Vaccination with as few as four tumor antigens generated antigen-specific responses, reduced intestinal tumors, and improved survival...
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Gilteritinib Improved Survival for Patients With Acute Myeloid Leukemia
“ATLANTA – Treatment with the FLT3-targeted therapeutic gilteritinib (Xospata) improved survival for patients with relapsed or refractory acute myeloid...
Excess Body Weight Before age 50 is Associated With Higher Risk of Dying From Pancreatic Cancer
ATLANTA – Excess weight before age 50 may be more strongly associated with pancreatic cancer mortality risk than excess...
Mesothelin-targeted CAR T-cell Therapy Safe, Shows Early Promise in Patients With Advanced Solid Tumors
ATLANTA – A chimeric antigen receptor (CAR) T-cell therapy that targets the protein mesothelin showed no evidence of major...
HER2-targeted CAR T-cell Therapy Safe, With Promising Antitumor Activity in Patients With Advanced Sarcoma
ATLANTA – A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2...
Immune Checkpoint Inhibitor Combination Efficacious For Patients With High-grade Neuroendocrine Carcinoma
ATLANTA – A combination of the anti-CTLA-4 immunotherapeutic ipilimumab (Yervoy) and the anti-PD-1 immunotherapeutic nivolumab (Opdivo) showed clinical benefit...
Adding the MET Inhibitor Savolitinib to Osimertinib was Beneficial for Certain Pretreated Lung Cancer Patients in TATTON Trial
ATLANTA – Adding the investigational MET inhibitor savolitinib to the EGFR inhibitor osimertinib (Tagrisso) yielded clinical responses in patients...
Survey of Young-onset Colorectal Cancer Patients Suggests Misdiagnosis May Be Common
PHILADELPHIA – Many patients diagnosed with colorectal cancer before age 50 were initially misdiagnosed, which may lead to diagnosis...
Liquid Biopsy-based Test As Good As Tissue-based Test for Identifying Treatment for Lung Cancer
Single test could identify one prognostic and seven predictive biomarkers in blood PHILADELPHIA – Guardant360, a liquid biopsy test...
Prostate Cancer Patients With Cardiovascular Disease Had Higher Mortality After Starting Abiraterone Acetate
Clinical trial data may not be generalizable to real-world population PHILADELPHIA – Patients with advanced prostate cancer who had...