Copanlisib-Rituximab Combination Cuts Lymphoma Progression or Death by Nearly Half in CHRONOS-3 Trial
PHILADELPHIA – A combination of copanlisib (Aliqopa) and rituximab led to a 48 percent reduction in the risk of...
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Healthy Lifestyle May Offset Risk of Lethal Prostate Cancer in Men With High Genetic Risk
PHILADELPHIA – Men who had a high genetic risk of developing prostate cancer were less likely to develop a...
Liquid Biopsy Augments MRI for Predicting Response to Neoadjuvant Treatment in Patients With Breast Cancer
PHILADELPHIA – A liquid biopsy test to assess plasma cell-free DNA (cfDNA) integrity could improve the accuracy of magnetic...
Immunotherapy Response Prediction Using Tumor Mutational Burden May Differ Between Men and Women With Melanoma
PHILADELPHIA – Tumor mutational burden (TMB) was an accurate predictor of response to treatment with immune checkpoint inhibitors for...
Unselected Autologous Tumor Infiltrating Lymphocyte Therapy Shows Early Promise in Patients With Metastatic Melanoma
PHILADELPHIA – Treatment with unselected autologous tumor infiltrating lymphocytes (TILs) showed early clinical efficacy among patients with advanced melanoma,...
Early-onset Colorectal Cancers from Patients of Different Races May Exhibit Distinct Genetic Features
PHILADELPHIA – Racial differences in genetic mutations were observed among early-onset colorectal cancers (CRC), according to data presented during...
CREB1 Identified as Potential Therapeutic Target for the Treatment of Pancreatic Cancer
PHILADELPHIA – Preclinical experiments using cell lines, genetic mouse models, and human pancreatic tumor tissue identified the transcription factor...
Personalized Cancer Vaccine Given After Adjuvant Therapy Safe, Shows Early Efficacy in Multiple Tumor Types
PHILADELPHIA – Treatment with the neoantigen cancer vaccine PGV-001 following standard-of-care adjuvant therapy was well tolerated and showed potential...
Oncolytic Herpesvirus Shows Early Promise in Pediatric Patients with High-grade Glioma
PHILADELPHIA – Treatment with a modified herpesvirus in combination with radiation therapy was well tolerated and showed signs of...
Bispecific CAR T-cell Therapy Shows Early Promise for Relapsed or Refractory B-cell Lymphoma
PHILADELPHIA – Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy...