I am an immunologist with a deep and long-lasting interest in how body’s immune response shapes cancer and tumor-microenvironment. I am addressing the role of B cells in regulating anti-tumor immunity in pancreatic cancer, with developing new immune-based therapy options for these deadly malignancy. My pre-clinical studies shows blockade of IL-35 producing B cells make pancreatic tumor more responsiveness towards immune-checkpoint blockade therapy. Therefore, my current research focused on design of combinatory therapeutic biologicals such as anti-IL-35 with anti-PD-1 or anti-CTLA-4 cancer immunotherapy along with biomarkers of response to therapy for effective and better treatment of pancreatic cancer patients.