Research Interests
Clinical and translational breast cancer research; cancer biology and treatment; role of apoptosis and mechanisms of epigenetic regulation of gene expression of the estrogen receptor alpha (ESR1) gene in breast cancer treatment.
Current Affiliations
Adjunct professor of oncology, Johns Hopkins University, Baltimore, Maryland; professor, Department of Medicine, University of Washington, Seattle, Washington; Raisbeck chair for collaborative cancer research and executive vice president, clinical affairs and professor, Fred Hutchinson Cancer Center, Seattle, Washington.
Previous Positions
Professor and division head, medical oncology, Department of Medicine, University of Washington (2016-2023), Seattle, Washington; adjunct professor of medicine (2016-2018); distinguished professor of medicine (2013-2016); professor, Clinical and Translational Science Institute (2010-2016); director, University of Pittsburgh Cancer Institute (2009-2016); and chief, Division of Hematology/Oncology (2009-2010), University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; professor of oncology (1999-2009), Breast Cancer Research Chair (1995-2009); associate professor of oncology (1992-1999); and assistant professor of oncology (1986-1992), Johns Hopkins University School of Medicine, Baltimore, Maryland; joint appointment, Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health (1997-2009), Baltimore, Maryland; director, Breast Cancer Program, Johns Hopkins Oncology Center (1994-2009), Baltimore, Maryland; active staff, Johns Hopkins Hospital (1986-2009), Baltimore, Maryland; research assistant professor of pharmacology, Uniformed Services University of Health Sciences (1985-1986), Bethesda, Maryland.
Education
MD, Harvard Medical School, Boston, Massachusetts (1979); BA, molecular biology, Wellesley College, Wellesley, Massachusetts (1975).
Postdoctoral Training
Medical staff fellow, National Cancer Institute (1982-1985), Bethesda, Maryland; resident, internal medicine, Johns Hopkins Hospital (1980-1982), Baltimore, Maryland; intern, internal medicine, Hospital of the University of Pennsylvania (1979-1980), Philadelphia, Pennsylvania.
Selected AACR Service, Honors, and Awards
Chair, AACR Distinguished Lectureship in Breast Cancer Research Committee (2022-2023); chair, AACR-Lobular Breast Cancer Alliance Invasive Lobular Carcinoma Research Grants Committee (2021-2022); steering committee member, Winn-AACR Design and Implementation of Clinical Trials Workshop (2021-2024); member, Science Policy and Government Affairs Committee (2020-2023); chair, Tellers Committee (2018-2019); member, AACR Award for Lifetime Achievement in Cancer Research Committee (2017-2021); elected Fellow, Fellows of the AACR Academy (2017); conference cochair, New Horizons in Cancer Research: Research Propelling Cancer Prevention and Cures (2017); cochair, EACR-AACR-SIC Conference: The Challenges of Optimizing Immuno- and Targeted Therapies: From Cancer Biology to the Clinic (2017); member, GENIE Steering Committee (2016-2018); president of the AACR (2015); member, AACR Distinguished Lectureship in Breast Cancer Research Award Committee (2012); chairperson (2011-2012) and member (2010-2011), Nominating Committee; member, AACR Outstanding Investigator Award for Breast Cancer Research Committee (2010); member (2009-2012) and chair (2012-2017), Continuing Medical Education Committee; chairperson, Breast Cancer Research Foundation-AACR Grants for Translational Breast Cancer Research Scientific Review Committee (2009); member, Dorothy P. Landon-AACR Prize for Translational Cancer Research Committee (2009); chairperson (2008-2010) and member (2005), Research Grant Review Committee; member, Stand Up To Cancer Innovative Research Grants Scientific Review Committee (2008-2009); member, Editorial Board, AACR Journal, Cancer Prevention Research (2008-Present); member, Scientific Program Committee, AACR International Conference on Frontiers in Cancer Prevention Research (2008); member, AACR Award for Lifetime Achievement in Cancer Research Committee (2005); member, Board of Directors (2002-2005); member, Special Conferences Committee (2002-2005); member, Clinical Cancer Research Committee (2001-2003); member, Career Development Awards Committee (2000); member, Richard and Hinda Rosenthal Foundation Award Committee (1999, 2002); member, Glaxo Welcome Oncology Clinical Research Scholar Award Committee (1998); member, Endocrinology Task Force (1997).
Selected Non-AACR Service, Honors, and Awards
Member, Board of Directors, Washington State Hospital Association (2023-present); member, Board of Directors, Zymeworks (2023-present); member, Board of Directors, Fred Hutchinson Cancer Center (2022-present); honoree, Giant of Cancer Care—Breast Cancer (2021); honoree, Puget Sound Business Journal 2021 Women of Influence (2021); honoree, Puget Sound Business Journal Power 100 (2020); awardee, Seattle Business Magazine, Leaders in Health Care Awards (2019); awardee, American-Italian Cancer Foundation Prize for Scientific Excellence in Medicine (2018); recipient, Allen S. Lichter Visionary Leader Award of ASCO (2018); member, Board of Directors, Ludwig Institute for Cancer Research and Ludwig Fund (2018-present); recipient, Jill Rose Award, Breast Cancer Research Foundation (2017); member, Board of Directors, V Foundation (2017-present); fellow (2016) and elected member (2007), American College of Physicians; honoree, Johns Hopkins University Society of Scholars (2016); honoree, the Johns Hopkins Women’s Medical Alumnae Assoc. Hall of Fame (2016); honoree, Thomson Reuter/Clarviate Highly Cited Researchers (2014, 2015, 2018); member, Scientific Advisory Committee, Breakthrough Breast Cancer, London (2014); recipient, Potamkin Award, Pennsylvania Breast Cancer Coalition (2012); elected member, Institute of Medicine of the National Academies (2011); member (2011-2023) and chair (2015-2018), Clinical Trials and Translational Research Advisory Committee (CTAC), National Cancer Institute; elected member, Association of American Physicians (2010); recipient, Gianni Bonadonna Breast Cancer Award, American Society of Clinical Oncology (2010); recipient, Distinguished Alumna Award, Johns Hopkins University Alumni Association (2009); member, Scientific Advisory Board, V Foundation for Cancer Research (2008-Present); recipient, AACR-Women in Cancer Research Charlotte Friend Award (2008); recipient, Rosalind E. Franklin Award for Women in Science, National Cancer Institute (2008); president (2007-2008) and member, Board of Directors (1996-1999), American Society of Clinical Oncology.