Program
Please Note: All session times for the 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research – Translating Knowledge into Practice are U.S. Hawaii–Aleutian Daylight (HDT).
Saturday, December 10, 2022
Sunday, December 11, 2022
Plenary Session 1: Tumor Microenvironment
Plenary Session 2: Cancer Genomics and Cancer Evolution
Plenary Session 3: Cancer Immunology
Monday, december 12, 2022
Plenary Session 4: Cancer Immunotherapy
Plenary Session 5: Preclinical Models; Organoids; Genetic and Transplantation Models
Plenary Session 6: Epigenetics; Cancer Plasticity and Heterogeneity; RNA Networks
Tuesday, december 13, 2022
Plenary Session 7: Cancer Metabolomics
Plenary Session 8: Genome Instability
Plenary Session 9: Genetic and Environmental Factors in Carcinogenesis
Wednesday, december 14, 2022
Plenary Session 10: Early Detection of Cancer
Plenary Session 11: Drug Resistance
Plenary Session 12: New Technologies for Cancer Imaging and Other Emerging Technologies
Saturday, december 10, 2022
Opening Keynote session
Session Cochairs: Antoni Ribas, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California, and Masanori Hatakeyama, Institute of Microbial Chemistry, Tokyo, Japan
6-7:30 p.m.
Introductory Remarks
Masanori Hatakeyama and Antoni Ribas
Reprogramming T Cells with CRISPR to enhance immunotherapy
Alexander Marson, University of California San Francisco, San Francisco, California
H. pylori infection, BRCAness, and gastric cancer
Masanori Hatakeyama
Opening Reception
7:30-9 p.m.
Sunday, december 11, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
Plenary Session 1: Tumor Microenvironment
Session Cochairs: Toshikazu Ushijima, Hoshi University, Tokyo, Japan, and Antoni Ribas, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California
8-9:30 a.m.
The aging microenvironment and its impact on tumor progression*
Ashani T. Weeraratna, Johns Hopkins University, Baltimore, Maryland
The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer
Naoko Ohtani, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
Mechanisms of neutrophil immune response in the bone metastatic prostate cancer
Leah M. Cook, University of Nebraska Medical Center, Omaha, Nebraska
*Presenting virtually
Break
9:30-10 a.m.
Plenary Session 2: Cancer Genomics and Cancer Evolution
Session Cochairs: Christina Curtis, Stanford University, Stanford, California, and Koshi Mimori, Kyushu University Beppu Hospital, Oita, Japan
10 a.m.-12 p.m.
Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome
Paul S. Mischel, Stanford University, Stanford, California
Genetic basis of pediatric cancers
Junko Takita, Kyoto University, Graduate School of Medicine, Kyoto, Japan
Genotype to phenotype mapping of tumorigenesis at single cell resolution
Christina Curtis
Translating cancer evolutionary insights into clinical practice
Mariam Jamal Hanjani, University College London Cancer Institute, London, United Kingdom
Free Time
12-4:00 p.m.
Plenary Session 3: Cancer Immunology
Session Cochairs: Nina Bhardwaj, The Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, New York, and Masanobu Oshima, Kanazawa University, Kanazawa, Japan
4-5:30 p.m.
Regeneration of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection
Hiroshi Kawamoto, Kyoto University, Kyoto, Japan
Properties of tumor antigens determining induction of immunity
Nina Bhardwaj
Chimeric antigen receptors targeting of truncated O-glycopeptides
Avery D. Posey, Jr., University of Pennsylvania, Philadelphia, Pennsylvania
poster session A
5:30-7:30 p.m.
Monday, december 12, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
Plenary Session 4: Cancer Immunotherapy
Session Cochairs: Antoni Ribas, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California, and Seiji Yano, Kanazawa University, Kanazawa, Japan
8-9:30 a.m.
Immune suppression by regulatory T cells in the tumor microenvironment
Hiroyoshi Nishikawa, National Cancer Center, Tokyo, Japan
When cancer cells enable an antitumor immune response
Antoni Ribas
Immune suppression by regulatory T cells in the tumor microenvironment
Hiroyoshi Nishikawa, National Cancer Center, Tokyo, Japan
Clonal evolution in a tumor microenvironment
Yosuke Togashi, Chiba Cancer Center, Kashiwa, Japan
Break
9:30-10 a.m.
Plenary Session 5: Preclinical Models; Organoids; Genetic and Transplantation Models
Session Cochairs: Issay Kitabayashi, National Cancer Center Research Institute, Tokyo, Japan and Alexander Marson, University of California San Francisco, San Francisco, California
10-11:30 a.m.
Modeling pancreatic cancer*
David A. Tuveson, Cold Spring Harbor Laboratory Cancer Center; Lustgarten Foundation, Cold Spring Harbor, New York
Polyclonal metastasis of genetically and phenotypically distinct intestinal tumor organoids
Masanobu Oshima, Kanazawa University, Kanazawa, Japan
Humanized mouse models for immuno-oncology studies
Anthony Rongvaux, Fred Hutchinson Cancer Center, Seattle, Washington
*Presenting virtually
free time
11:30 a.m.-4:30 p.m.
Plenary Session 6: Epigenetics; Cancer Plasticity and Heterogeneity; RNA Networks
Session Cochairs: Junko Takita, Kyoto University, Kyoto, Japan and Patrick Tan, Duke-NUS Medical School, Singapore, Singapore
4:30-5:30 p.m.
Essential roles of TIP60 in acute myeloid leukemia with NPM mutation
Issay Kitabayashi, National Cancer Center Research Institute, Tokyo, Japan
Dissecting the mechanisms for cancer development caused by aberrant splicing
Daichi Inoue, Institute of Biomedical Research and Innovation, Kobe, Japan
poster session b
5:30-7:30 p.m.
Tuesday, december 13, 2022
Continental Breakfast
7-8 a.m.
PLENARY SESSION 7: CANCER METABOLOMICS
Session Cochairs: Susan M. Kaech, Salk Institute, La Jolla, California, and Naoko Ohtani, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
8-9:30 a.m.
Targeting NAD biogenesis in lung and prostate neuroendocrine carcinomas
Nobuhiro Tanuma, Miyagi Cancer Center, Miyagi, Japan
Co-opting immune cells to support cancer progression through metabolic reprogramming
Susan M. Kaech
Cancer metabolism within the tumor microenvironments
Tsuyoshi Osawa, The University of Tokyo, Tokyo, Japan
break
9:30-10 a.m.
PLENARY SESSION 8: GENOMIC INSTABILITY
Session Chair: Yoshinori Murakami, The University of Tokyo, Tokyo, Japan
10-11 a.m.
The labile control of mitotic chromosome segregation underlies chromosomal instability in cancer cells
Toru Hirota, The Cancer Institute Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan
Maintenance of genome integrity and chemoresistance by BRCA1 tumor suppressor
Natsuko Chiba, Tohoku University, Miyagi, Japan
free time
11 a.m.-4 p.m.
Plenary Session 9: Genetic and Environmental Factors in Carcinogenesis
Session Cochairs: Melissa B. Davis, Weill Cornell Medicine, New York, New York, and Tatsuhiro Shibata, The University of Tokyo, Tokyo, Japan
4-5:30 p.m.
How ancestry leads to the DARC side of breast cancer disparities
Melissa B. Davis
Molecular assessment of pre-malignant lesions in stomach cancer
Patrick Tan, Duke-NUS Medical School, Singapore, Singapore
Comprehensive analyses of genome and DNA adducts elucidate association between environmental factors and human cancer development
Yukari Totsuka, National Cancer Center, Tokyo, Japan
Poster session c
5:30-7:30 p.m.
Wednesday, december 14, 2022
Continental Breakfast
7-8 a.m.
Plenary Session 10: Early Detection of Cancer
Session Cochairs: Tomoki Todo, The University of Tokyo, Tokyo, Japan, and John M. Carethers, University of Michigan, Ann Arbor, Michigan
8-9:30 a.m.
Allele – environment interplay in Asian gastric cancer
Shumpei Ishikawa, The University of Tokyo, Tokyo, Japan
Fecal and tissue DNA for diagnosis and prognosis of colorectal cancer
John M. Carethers
Exosomal proteins in cancer: Roles in cancer metastasis and biomarker potential
Ayuko Hoshino, Tokyo Institute of Technology, Tokyo, Japan
break
9:30-10 a.m.
Plenary Session 11: Drug Resistance and Preclinical Models in Cancer Research
Session Cochairs: Katerina Politi, Yale Cancer Center, New Haven, Connecticut, and Noriko Gotoh, Kanazawa University, Kanazawa, Japan
10-11:30 a.m.
Mechanisms of resistance to systemic therapies in lung cancer
Katerina Politi
Drosophila approaches toward cancer mechanisms and therapeutics
Masahiro Sonoshita, Hokkaido University, Hokkaido, Japan
Models and strategies to study acral melanoma from Latin American patients
Patricia A. Possik, Brazilian National Cancer Institute, Rio de Janeiro, Brazil
Free time
11:30 a.m.-4 p.m.
Plenary Session 12: New Technologies for Cancer Imaging and Other Emerging Technologies
Session Cochairs: Toru Hirota, The Cancer Institute Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, and Anna M. Wu, City of Hope, Duarte, California
4-5:30 p.m.
Visualizing immune responses using immunoPET
Anna M. Wu
Clinical applications of intraoperative fluorescence imaging to hepatobiliary and pancreatic surgery
Kenjiro Kimura, Osaka Metropolitan University, Osaka, Japan
Molecular imaging of receptor membrane dynamics to reverse drug resistance in cancer
Patricia Ribeiro Pereira, Washington University School of Medicine, St. Louis, Missouri