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Progress Against Cancer

Home Patients, Caregivers, and Advocates Progress Against Cancer Research Page 23

Recent Progress: Research Updates

Hypoxia and the Lethal Cancer Phenotype: A Conversation with Nobel Laureate Gregg Semenza

Hypoxia and the Lethal Cancer Phenotype: A Conversation with Nobel Laureate Gregg Semenza

In the early 1990s, Gregg Semenza, MD, PhD, was a postdoctoral researcher studying the cellular response to reduced oxygen levels, a state known as hypoxia. His focus was on the erythropoietin gene, EPO, which controls red blood cell production, and thus oxygen delivery. After identifying a sequence within the EPO gene that was critical for the response to hypoxia, Semenza isolated a mystery protein that was bound to this sequence.